Monday, 8th February
The 46th Lorne Conference on Protein Structure and Function 2021
Days
Monday, 8th February
Tuesday, 9th February
Wednesday, 10th February
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Speakers
Session 1 - Pathogens
10:00AM - 11:20AM
Monday, 8th February
Chairs: Melissa Call & Rhys Grinter
Structure-Function Studies of the SARS-CoV-2 Spike and Development of COVID-19 Interventions
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Jason McLellan
Interactions of Poly-C-binding protein 2 with the poliovirus type I IRES
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Jackie Wilce
Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance
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Tuo Yang
Morning Tea
11:20AM - 11:40AM
Monday, 8th February
Session 2 - COVID-19
11:40AM - 12:40PM
Monday, 8th February
Chairs: Colin Jackson & Lakshmi Wijeyewickrema
The evolutionary potential of the SARS-CoV-2 receptor binding domain
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Jesse Bloom
Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2
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Theresa Klemm
Lunch
12:40PM - 1:30PM
Monday, 8th February
Session 3 - Lightning Talks
1:30PM - 2:30PM
Monday, 8th February
Chairs: Bostjan Kobe & David Ascher
Uncovering the mechanism of a threonine-specific ubiquitin E3 ligase
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Peter D Mabbitt
Structural and functional characterisation of mitochondrial complex IV assembly factors
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Shadi Maghool
Molecular coupling between transcription and DNA repair machinery in live cells during transcriptional stress
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Harshad Ghodke
Protein liquid-to-solid phase transition from condensates
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Yi Shen
Mono-ubiquitination by the Fanconi anaemia core complex clamps FANCI:FANCD2 on DNA as a filamentous array
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Winnie Tan
Free Time/Online Workshops/Poster Viewing
2:30PM - 7:00PM
Monday, 8th February
Posters Live Discussion - Session 1A
4:30PM - 5:15PM
Monday, 8th February
Cholesterol modulates glycine transporter kinetics and pharmacology
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Zachary J Frangos
Varicella zoster virus encodes an amyloid ‘decoy’ inhibitor of apoptosis
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Max Baker
Small molecule inhibitors modulate the glycine transporter 2 by interacting at an allosteric site
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Ryan Cantwell Chater
Proteome-scale discovery of protein interactions with residue-level resolution using sequence coevolution
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Hadeer Elhabashy
The Commander Protein Complex and its Role in Intracellular Membrane Trafficking
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Michael D Healy
Enzyme technology for textile waste-water treatment
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Nabangshu Sharma
Targeting TIR domain assemblies in TLR signalling pathways to design anti-inflammatory compounds
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Md Habibur Rahaman
Structure and function of a novel venom-derived peptide from an Australian sea anemone
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Khaled Mr. Elnahriry
A reductionist approach for studying the ASIC thumb domain to screen for channel modulators as novel therapeutic leads
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Biswa Prasanna Mishra
Substrate processing by the p97 ATPase in complex with its cofactors
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Abolfazl Mirzadeh
Understanding the activation mechanism of pseudokinase MLKL in the necroptosis pathway
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Yanxiang Meng
Understanding structural determinants of amylin receptors binding and G protein activation
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Jianjun Cao
Molecular modelling of the structure of fungal effector proteins
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Lina Rozano
Structural basis of epitope promiscuity within the HLA-A3 super family
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Andrea T Nguyen
strumNHEJ - A structural database of mutations in NHEJ repair leading to cancer and their molecular consequences
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Raghad Al Jarf
Understanding the effect of R155P mutant associated with multisystem proteinopathy on AAA+ ATPase p97
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Sepideh Valimehr
Cryo-EM studies of the BAK: VDAC2 complex from mammalian cells
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Zheng Yuan
Disorder brings order: the roles of intrinsically disordered proteins in parasite antigen trafficking in the
Plasmodium falciparum-
infected red blood cell
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Olivia M. S. Carmo
The interaction of apoA-I with lipid monomers and implications for amyloid fibril formation
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Phoebe Tou
How to routinely get sub 2.5 Angstrom resolution GPCRs structures by single particle cryoEM
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Matthew Belousoff
MX3 - a high throughput, high automation beamline coming to your Australian Synchrotron in 2023.
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Daniel Eriksson
A Fab-tag for small membrane protein structure determination
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Benjamin C McIlwain
BonA from
Acinetobacter baumannii
forms a divisome-localized decamer that supports outer envelope function
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Rhys Grinter
Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation
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Brett Collins
Posters Live Discussion - Session 2A
5:15PM - 6:00PM
Monday, 8th February
Differential GLP-1R binding and activation by peptide and non-peptide agonists
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Xin Zhang
Structural basis of NMN-induced SARM1 activation in axon degeneration
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Weixi Gu
Using a lentiviral mammalian cell directed evolution platform to engineer highly expressing oxytocin and vasopressin 1
A
receptor variants
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Lisa M Williams
Modulation of Mycobacterium tuberculosis isocitrate lyase through metabolites
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Brooke X.C. Kwai
Identification and Characterisation of lipids that are positive allosteric modulators of glycine receptors
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Casey I Gallagher
Fast-responding electrochemical protein biosensors for novel diagnostic applications
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Cagla Ergun Ayva
Identification and validation of new chemical scaffolds for Hsp90
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Eva Antony
Sequence-independent electrostatic interactions between PRC2–PCL complexes and DNA
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Brady M Owen
Development of a high affinity peptide inhibitor of the human sliding clamp, PCNA
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Aimee J Horsfall
Bioinformatics and virtual screening of the AAA+ ATPase p97 in protozoan parasites and mycobacteria
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George G Kobakhidze
Directed evolution of the relaxin family peptide receptor 1 (RXFP1) to facilitate cryo-EM studies
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Jonathan Siah
Biophysical and Structural Characterisation of Long-acting Inhibitors of the PCSK9:EGFA Protein-Protein Interaction
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Yuhui Zhang
Structural, mechanistic and inhibition studies of
Mycobacterium tuberculosis
2-oxoglutarate-dependent dioxygenase RV3406
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Tzu-Jung Juan
Non-lysine ubiquitination: Biochemical characterisation of the RING-between-RING E3 ubiquitin ligase, HOIL-1L
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Xiangyi Wang
Investigating the interaction between JAK1 FERM-SH2 and box 1 of class II cytokine receptors
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Amarachi Amah
Re-designing pore structure in self-assembling protein cages
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Nuren Tasneem
Chemical inhibitors of telomeric PPIs in ALT positive cancers
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Haritha Krishna Sudhakar
Understanding the formation of a novel two-component membrane pore by pore-forming toxins structurally related to cholesterol-dependent cytolysins
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Bronte A. Johnstone
Structural characterization of SARS-CoV-2 peptides presented by Human Leukocyte Antigen molecules
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Christopher Szeto
New Intermediates and New Reactions of Cysteine Dioxygenase
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Guy N L Jameson
Structural and functional characterization of MlaD from
Acinetobacter baumannii
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Jing Zhang
Computational investigation, prediction and mapping of anti-CRISPR proteins
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Jiawei Wang
Structural basis for K63-ubiquitin chain formation by the Gordon-Holmes Syndrome E3 ligase RNF216
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Thomas Cotton
Session 4 - The EMBL Session
7:00PM - 8:45PM
Monday, 8th February
Chairs: James Whisstock & Peter Czabotar
Molecules to ecosystems : structure in the new world of biology
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Ewan Birney
A front row seat – science in Aotearoa New Zealand’s COVID-19 response
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Juliet Gerrard
Structural insights into the cytoplasmic exosome, a cellular mRNA quality control machinery
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Eva Kowalinski
Happy Hour & Trade Display
8:30PM - 9:30PM
Monday, 8th February
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