Tuesday, 9th February
The 46th Lorne Conference on Protein Structure and Function 2021
Days
Monday, 8th February
Tuesday, 9th February
Wednesday, 10th February
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Speakers
Session 5 - Cryo-EM
10:00AM - 11:00AM
Tuesday, 9th February
Chairs: Charlie Bond & Katrina Black
CryoEM: Better, faster, cheaper
-
Bridget Carragher
Glutamate transporters contain a conserved chloride channel with two hydrophobic gates
-
Josep Font Sadurni
Morning Tea
11:00AM - 11:20AM
Tuesday, 9th February
Session 6 - Aggregation and Disease
11:20AM - 12:20PM
Tuesday, 9th February
Chairs: Margie Sunde & Debnath Ghosal
Functional amyloid and its conversion to pathogenic amyloid
-
David Eisenberg
The regulation of protein disaggregation function in human cells
-
Nadinath B Nillegoda
Lunch
12:20PM - 1:10PM
Tuesday, 9th February
Session 7 - Anders Young Investigator Awards
1:20PM - 2:30PM
Tuesday, 9th February
Chairs: Tatiana Soares da Costa & Jeffrey Nanson
Structure of the bacterial flagellar MS-ring: An adaptor between secretion and rotation
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Emily J Furlong
Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues
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Katherine A Davies
Molecular basis underpinning metabolite-mediated T-cell immunity
-
Wael Awad
Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization.
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Nicholas PD Liau
ThermoFisher Workshop
2:30PM - 3:30PM
Tuesday, 9th February
Free Time/Online Workshops/Poster Viewing
2:30PM - 5:00PM
Tuesday, 9th February
ECR/Student Event
3:30PM - 4:45PM
Tuesday, 9th February
Posters Live Discussion - Session 1B
5:00PM - 5:30PM
Tuesday, 9th February
Development of stapled peptides inhibiting the interaction between FANCM and RMI complex as a possible therapeutic strategy for ALT cancers
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Tianyi Gao
Development of macrocyclic peptide inhibitor that targets genome instability in ALT+ cancers
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Quynh Vu
Diversion of Aβ42 to non-toxic aggregates by a monomer sequestration mechanism
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Sarah R Ball
Characterising novel
Coxiella burnetii
effector protein interactions
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Cameron C. Oppy
A nitrite oxidoreductase drives respiration during carbon starvation in the soil bacteria
Mycobacterium smegmatis
.
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David L Gillett
Structural studies of α1-Adrenoreceptors using phospholipid bilayer models
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Mohammad Hossein Tanipour
Mapping the signaling events underlying RIPK3 activation of MLKL during necroptosis
-
Sarah E Garnish
The Transmembrane Organisation of the B Cell Antigen Receptor
-
Samyuktha Ramesh
Inhibition studies of ketol-acid reductoisomerase from pathogenic microorganims
-
Shun Jie Wun
Developing a new proteomics methods for proximity-based labeling interactors of nascent Huntingtin protein
-
Ruohua Lyu
A novel binding mechanism of H2 relaxin to the human Glucocorticoid Receptor
-
Shatabdi Chakraborty
Ab initio
structural prediction of candidate fungal effector proteins
-
Yvonne M Mukuka
Molecular dynamics of encapsulin pore mutants
-
Eric N. Jenner
My pET project: Improving plasmid design for increased protein production
-
Patrick J Shilling
Understanding the molecular recognition of
Bacteroides fragilis
glycosphingolipids by Natural killer T-cell receptor
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Praveena Thirunavukkarasu
Dynamic drug targets: Cryo-EM structures of active G-protein coupled receptors
-
Sarah Piper
High-throughput screens for small molecules targeting SARS-CoV-2 Main protease
-
Marija Dramicanin
Unravelling the features of T cell Response to a Gag Epitope in HIV+ Controllers
-
Dimitra SM Chatzileontiadou
Targeting
Plasmodium falciparum
tyrosyl-tRNA synthetase for the development of new antimalarials
-
Elyse A Dunn
Cryo-electron tomography explains the structural basis of endosomal trafficking
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Natalya Leneva
Novel approach to determining inactive GPCR structures using cryo-EM
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Rachel M Johnson
Metal Dependent Dynamic Equilibrium: A Regulatory Mechanism for M17 Aminopeptidases from
Plasmodium falciparum
and
Plasmodium vivax
-
Tess Malcolm
Deciphering the assembly and signalling mechanisms of the unique BAFF 60-mer through the TACI cytokine receptor
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Karen S Cheung Tung Shing
Nucleotide-dependent conformational changes in the AAA ATPase p97 and a disease-causing mutant revealed by Cryo-Electron Microscopy and Mass Spectrometry
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Ashish Sethi
Posters Live Discussion - Session 2B
5:30PM - 6:00PM
Tuesday, 9th February
Towards the development of herbicide cocktails targeting lysine biosynthesis
-
Emily Mackie
The Complexity of Receptor Signalling in Defecation Control: Mechanisms of Interaction Between Ghrelin and Dopamine D2 Receptors
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Emily Whitfield
Molecular Mechanism for Modulation of Cholecystokinin 1 Receptor Coupling by Cholesterol
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Michelle Xu
Understanding the molecular pathway of SARM1 regulation
-
Forhad K Saikot
Ribosomal stalling induced by arginine-rich dipeptide repeat proteins in amyotrophic lateral sclerosis
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Viacheslav Kriachkov
Engineering an optimized analgesic from the Na
V
1.7 selective tarantula venom peptide Pn3a
-
Alexander Mueller
Small Molecule Inhibitor of Necroptosis Targets Multiple Protein Effectors to Potently Block Cell Death
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Catia L Pierotti
Exploration of the β-amyloid generation pathways of γ-secretase via metadynamics
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Melissa Eccles
Biophysical and structural studies of CtrB, a polysaccharide co-polymerase from
Neisseria meningitidis
-
Lorelei Masselot--Joubert
De Novo
Designed Receptor Transmembrane Domains Modulate CAR-T Cell Function
-
Nick Chandler
Investigating diaminopimelate decarboxylase as a potential antibiotic target against multi-drug resistant
Pseudomonas aeruginosa.
-
Daniel A Hawkins
Structural characterization and lipid-binding properties of TACAN ion channel implicated in pain sensing
-
Nazanin Mohebali
Unexpected properties of a resurrected ancestral TIM-barrel glycosidase and its bioengineering implications
-
Luis I. Gutierrez-Rus
Engineering Extracellular Vesicles to Target At-Risk Cells in SARS-CoV-2: EVPS
TM
in Fortrexo CoV
-
Kartini Asari
ANSTO’s National Deuteration Facility: a molecular deuteration platform for characterisation studies in drug discovery and development.
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Karyn L Wilde
The design and engineering of synthetic carboxysomes using encapsulin protein cages
-
Taylor N Szyszka
Characterization of the effect of disease-causing genetic variants using protein 3D structural alterations
-
Sergio Ruiz-Carmona
Granulovirus PK-1 kinase activity relies on dimerisation via the N-lobe and αC helix
-
Chris R. Horne
Replisome bypass of a protein-based R-loop block by Pif1.
-
Lisanne M. Spenkelink
Widespread remodelling of proteome solubility in response to different protein homeostasis stresses
-
Xiaojing Sui
The structure of the BAMLET anti-cancer complex revealed by small angle X-ray and neutron scattering
-
Emma M Rath
Role of extracellular loop 5 of the β-barrel domain in folding of autotransporter EspC and Tsh passenger domains
-
Yichi Zhang
Functional and structural characterization of RpeA, a putative autotransporter adhesin from Rabbit enteropathogenic
Escherichia coli
-
Xiaoxu Yang
Characterising the interplay between MlaD and MlaC from
Acinetobacter baumannii
, and their interactions with phospholipids
-
jiansi long
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